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Nuclear Receptor & In Vitro Toxicology Solutions™

Free Scientific Poster:

Examination of Drug-Induced Liver Injury in upcyte® Hepatocytes

Liver toxicity is a major cause of drug failure in clinical trials and leads to the market withdrawal of many approved drugs today. Due to species differences in drug metabolism, it’s also difficult to extrapolate results obtained from preclinical animal models to humans. But upcyte® hepatocytes may be the key to reducing attrition from metabolism-mediated toxicity and improving the safety of drug candidates. Discover the results of one study by INDIGO Biosciences that examined cytotoxicity in upcyte® cells from four different donors for twelve compounds. This free scientific poster shares details of the study and explores the utility of upcyte® cells for screening compounds for hepatotoxicity and the rapid assessment of variability in humans for hepatotoxic responses.

Download this informative resource today to learn more about drug-induced liver injury (DILI) in upcyte® hepatocytes and enhance your own research.

 

Download this poster today

This Poster Will Discuss:

  • The utility of upcyte® cells for screening compounds for hepatotoxicity
  • The sensitivity of upcyte® hepatocytes to a variety of known hepatotoxicants
  • The ability of upcyte® cells to bioactivate compounds using cytochrome P450 inhibitors
  • The rapid assessment of variability in humans for hepatotoxic responses

upcyte® cells are proliferating human hepatocytes that retain important drug metabolizing enzymes, such as cytochrome P450 3A4 (CYP3A4), which make them an attractive model system to examine drug-induced liver injury.

Why Choose Us?

Get what you need from the world's largest portfolio of nuclear receptors

INDIGO has the largest portfolio of cell-based nuclear receptor assays in the world, helping you identify compounds with the highest selectivity and the lowest potential for unwanted effects and off-target responses. Our broad portfolio of nuclear receptors makes us the preferred source for single receptor or full-panel screenings. Whether for nuclear receptor or in vitro toxicology solutions, our intellectual property, ease of use, and quick turnarounds will get you to the next phase of discovery, faster.

Make confident decisions with clear results about your compounds

To empower confident decision-making throughout the discovery process, INDIGO’s technology generates clear single receptor or full-panel screening results, making for better interpretation and more accurate data. Employing a luminescence-based method and our proprietary CryoMite™ preservation process, we provide reproducible results lot to lot about the efficacy, potency, and selectivity of your compounds, plus comprehensive lab reports that include helpful graphics, summaries, and insights.

Be supported in your study with a committed team of experts

INDIGO is a leading provider of nuclear receptor and in vitro toxicology solutions, recognized for our focus on client support. Committed to accelerating the discovery process for you, our team goes the extra mile by offering complimentary study consults, designs, and research, and providing a comprehensive review of the results with you. As objective experts focused on your success, it’s our duty to ensure the results we provide inform assured next steps.

Save time and money with accelerated lab results and decisions

At INDIGO, our cell-based assay kits and services accelerate scientific decision-making by reducing time, cost, and risk associated with the discovery process. We know that time is money during discovery and aim to get you to the next phase faster or prevent unnecessary steps forward. For quick data and decisions, our kits deliver results in just 24 hours. And, beyond saving time, our kits and services also provide the most comprehensive data for your investment.

Screen your compounds using reliable science, platforms, and people

INDIGO provides a superior combination of expertise, kits, services, and support to leading through startup organizations, ranging from pharmaceutical companies and biotechs to university labs and CROs. Lab directors across the globe trust us for single receptor or full-panel screenings at every stage of discovery, leveraging our industry-leading platforms, knowledgeable people, and proprietary science.

About Us

INDIGO Biosciences, Inc. (INDIGO) is a leading provider of nuclear receptor and in vitro toxicology solutions that accelerate scientific decision-making. We supplement the world’s largest portfolio of nuclear receptor kits and services and in vitro toxicology solutions with greater results readability, reproducibility, accuracy, and turnaround times. Our solutions, plus supportive team and reliable science and platforms, aim to reduce the time, cost, and risk associated with the discovery process.