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Free Scientific Poster:

Examination of Drug-Induced Liver Injury in upcyte® Hepatocytes

Liver toxicity is a major cause of drug failure in clinical trials and leads to the market withdrawal of many approved drugs today. Due to species differences in drug metabolism, it’s also difficult to extrapolate results obtained from preclinical animal models to humans. But upcyte® hepatocytes may be the key to reducing attrition from metabolism-mediated toxicity and improving the safety of drug candidates. Discover the results of one study by INDIGO Biosciences that examined cytotoxicity in upcyte® cells from four different donors for twelve compounds. This free scientific poster shares details of the study and explores the utility of upcyte® cells for screening compounds for hepatotoxicity and the rapid assessment of variability in humans for hepatotoxic responses.

Download this informative resource today to learn more about drug-induced liver injury (DILI) in upcyte® hepatocytes and enhance your own research.

 

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This Poster Will Discuss:

  • The utility of upcyte® cells for screening compounds for hepatotoxicity
  • The sensitivity of upcyte® hepatocytes to a variety of known hepatotoxicants
  • The ability of upcyte® cells to bioactivate compounds using cytochrome P450 inhibitors
  • The rapid assessment of variability in humans for hepatotoxic responses

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INDIGO has the largest portfolio of cell-based nuclear receptor assays in the world, helping you identify compounds with the highest selectivity and the lowest potential for unwanted effects and off-target responses. Our broad portfolio of nuclear receptors makes us the preferred source for single receptor or full-panel screenings. Whether for nuclear receptor or in vitro toxicology solutions, our intellectual property, ease of use, and quick turnarounds will get you to the next phase of discovery, faster.

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About Us

INDIGO Biosciences, Inc. (INDIGO) is a leading provider of nuclear receptor and in vitro toxicology solutions that accelerate scientific decision-making. We supplement the world’s largest portfolio of nuclear receptor kits and services and in vitro toxicology solutions with greater results readability, reproducibility, accuracy, and turnaround times. Our solutions, plus supportive team and reliable science and platforms, aim to reduce the time, cost, and risk associated with the discovery process.