One nuclear receptor with the ability to associate with a wide range of xenobiotics, including pharmaceutical agents, natural products, and environmental chemicals is pregnane X receptor (PXR). Activation of PXR regulates the expression of xenobiotic metabolizing enzymes such as cytochrome P450 and glutathione-S-transferases, as well as important drug transporters (P-glycoprotein, multidrug resistance protein). The PXR ligand binding domain is unusually divergent across species, compared to other nuclear receptors, with only 50% sequence identity between mammalian and non-mammalian PXR sequences. With such a pronounced difference, the ability to extrapolate human PXR activity from laboratory animal species is an important aspect of addressing the potential of drug-drug interactions with a new drug lead.
In this whitepaper from INDIGO Biosciences, a group of known PXR agonists is examined for their ability to regulate the activity of human, monkey, dog, rat, and mouse orthologues of PXR.
Download this informative resource today for insights on the unique profiles observed for each orthologue of PXR and to learn more about the observed species differences in both potency and efficacy of the chemicals examined.
Download the whitepaper to explore how PXR activation differs across human and common laboratory animal species, with insights into potency, efficacy, and translational relevance.
INDIGO has the largest portfolio of cell-based nuclear receptor assays in the world, helping you identify compounds with the highest selectivity and the lowest potential for unwanted effects and off-target responses. Our broad portfolio of nuclear receptors makes us the preferred source for single receptor or full-panel screenings. Whether for nuclear receptor or in vitro toxicology solutions, our intellectual property, ease of use, and quick turnarounds will get you to the next phase of discovery, faster.
To empower confident decision-making throughout the discovery process, INDIGO’s technology generates clear single receptor or full-panel screening results, making for better interpretation and more accurate data. Employing a luminescence-based method and our proprietary CryoMite™ preservation process, we provide reproducible results lot to lot about the efficacy, potency, and selectivity of your compounds, plus comprehensive lab reports that include helpful graphics, summaries, and insights.
INDIGO is a leading provider of nuclear receptor and in vitro toxicology solutions, recognized for our focus on client support. Committed to accelerating the discovery process for you, our team goes the extra mile by offering complimentary study consults, designs, and research, and providing a comprehensive review of the results with you. As objective experts focused on your success, it’s our duty to ensure the results we provide inform assured next steps.
At INDIGO, our cell-based assay kits and services accelerate scientific decision-making by reducing time, cost, and risk associated with the discovery process. We know that time is money during discovery and aim to get you to the next phase faster or prevent unnecessary steps forward. For quick data and decisions, our kits deliver results in just 24 hours. And, beyond saving time, our kits and services also provide the most comprehensive data for your investment.
INDIGO provides a superior combination of expertise, kits, services, and support to leading through startup organizations, ranging from pharmaceutical companies and biotechs to university labs and CROs. Lab directors across the globe trust us for single receptor or full-panel screenings at every stage of discovery, leveraging our industry-leading platforms, knowledgeable people, and proprietary science.
INDIGO Biosciences, Inc. is a leading provider of nuclear receptor and in vitro toxicology solutions that accelerate scientific decision-making. We supplement the world’s largest portfolio of nuclear receptor kits and services and in vitro toxicology solutions with greater results readability, reproducibility, and faster turnaround times. Our solutions, plus supportive team and reliable science and platforms, aim to reduce the time, cost, and risk associated with the discovery process.