Cell-based in vitro bioassays have been used in environmental monitoring to detect and quantify the presence of micropollutants in water samples. These assays provide scientists with a rapid, sensitive and cost-effective tool for evaluating the impact that environmental contaminants may have on biological activity.
However, the complexity of chemical mixtures in environmental matrices makes it difficult to choose which cellular response pathways to evaluate. The typical workflow for evaluating bioactivity of environmental samples is to either use previous studies to predict which pathways are important or to sequentially evaluate many different assays to determine which are being impacted. The former approach has a tendency for false-negative conclusions, whereas the latter is cost prohibitive in most cases. These challenges raise an interesting question: Is there a better way to determine what pathways are impacted by individual contaminants as well as complex mixtures? The answer is yes!
Learn more about how this alternative assay workflow can help researchers reduce the time and cost of evaluating complex mixtures.
INDIGO Biosciences is a leading provider of cell-based luciferase reporter assays. Our products and services are used in a broad range of industries such as environmental, drug discovery, academia, and contract research organizations. INDIGO assays are available as turnkey kits for use by scientists, or INDIGO can perform the assays in our own lab as a service. INDIGO’s assays have been demonstrated to provide fast, accurate, reproducible results, and we are dedicated to supporting scientists through reliable science, easy-to-use products, and a highly qualified technical support team. Learn more at indigobiosciences.com.